Pulmonary arterial hypertension (PAH) is high blood pressure in the pulmonary arteries caused by restricted blood flow.1

Normal Heart

Pulmonary Hypertension

Narrowing of the pulmonary arteries forces the heart to work harder to deliver blood to the body.1‍-‍3

This extra strain can lead to heart enlargement and even heart failure.1‍,‍2‍,‍4

Symptoms of PAH

Symptoms of PAH are caused by lack of oxygen due to narrowed blood vessels in the lungs and increased stress on the heart.5

PAH symptoms include5*:

  • Shortness of breath (dyspnea)
  • Fatigue (feeling tired all the time)
  • Chest pain or discomfort
  • Swollen ankles and legs (edema)
  • Fainting or light-headedness

*VELETRI® (epoprostenol) for Injection is not approved to treat all of the symptoms of PAH.6

References: 1. McLaughlin V. Pulmonary hypertension. In: Goldman L, Schafer AI, eds. Goldman’s Cecil Medicine. 24th ed. Philadelphia, PA: Elsevier Saunders; 2012:389-397. 2. Gomberg-Maitland M, Bull TM, Saggar R, et al. New trial designs and potential therapies for pulmonary artery hypertension. J Am Coll Cardiol. 2013;62(suppl D):D82-D91. 3. McLaughlin VV, Archer SL, Badesch DB, et al. ACCF/AHA 2009 expert consensus document on pulmonary hypertension. J Am Coll Cardiol. 2009;53:1573-1619. 4. Howard LS. Prognostic factors in pulmonary arterial hypertension: assessing the course of the disease. Eur Respir Rev. 2011;20:236-242. 5. Brown LM, Chen H, Halpern S, et al. Delay in recognition of pulmonary arterial hypertension: factors identified from the REVEAL registry. Chest. 2011;140:19-26. 6. VELETRI® (epoprostenol) for Injection Full Prescribing Information. Actelion Pharmaceuticals US, Inc.